Small GTPases of the Arf family are best known for their role in vesicular transport, wherein they nucleate the assembly of coat proteins at sites of carrier vesicle formation. However, accumulating evidence indicates that the Arfs are also important regulators of actin cytoskeleton dynamics and are involved in a variety of actin-based processes, including cell adhesion, migration and neurite outgrowth. The mechanisms of this regulation are remarkably diverse, ranging from the integration of vesicular transport with cytoskeleton assembly to the direct regulation of Rho-family GTPase function. Here, we review recent progress in our understanding of how Arfs and their interacting proteins function to integrate membrane and cytoskeletal dynamics.

中文翻译：

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Arf 家族 GTP 酶对肌动蛋白细胞骨架动力学的调节。

Arf 家族的小 GTP 酶以其在囊泡运输中的作用而闻名，其中它们在载体囊泡形成位点使外壳蛋白的组装成核。然而，越来越多的证据表明，Arfs 也是肌动蛋白细胞骨架动力学的重要调节器，并参与各种基于肌动蛋白的过程，包括细胞粘附、迁移和神经突生长。这种调节的机制非常多样化，从囊泡运输与细胞骨架组装的整合到 Rho 家族 GTPase 功能的直接调节。在这里，我们回顾了我们对 Arfs 及其相互作用蛋白如何整合膜和细胞骨架动力学的理解的最新进展。