Interleukin-10 (IL-10) is a pleiotropic cytokine that modulates the function of several adaptive immunity-related cells. Although generally considered an immunosuppressive molecule, IL-10 possesses immunostimulatory properties in several in vitro and in vivo models. These very different outcomes are believed to depend upon experimental conditions, the dominant immune effector mediating a given immune response, the timing of IL-10 production/administration, and IL-10 dose and/or location of expression. In the present work, we review the current knowledge regarding IL-10 activity on adaptive immunity related cells, emphasize new insights on IL-10 molecular/cellular targets, and summarize the available data on the relationship between IL-10 and some pathological conditions (e.g. infectious diseases, autoimmunity, allergy, cancer and transplantation) involving adaptive immunity.

中文翻译：

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IL-10与适应性免疫之间的多方面关系：将难题拼凑在一起。

白细胞介素10（IL-10）是一种多效性细胞因子，可调节多种适应性免疫相关细胞的功能。尽管通常认为IL-10是一种免疫抑制分子，但IL-10在几种体外和体内模型中均具有免疫刺激特性。认为这些非常不同的结果取决于实验条件，介导给定免疫反应的主要免疫效应子，IL-10产生/施用的时间以及IL-10的剂量和/或表达位置。在目前的工作中，我们回顾了有关IL-10在适应性免疫相关细胞上的活性的当前知识，强调了关于IL-10分子/细胞靶标的新见解，并总结了关于IL-10与某些病理状况之间关系的可用数据（例如传染病，自身免疫，过敏，