All osteogenic cells (osteoclasts, osteoblasts) contribute individually to bone remodeling. Their cellular interactions control their cellular activities and the bone remodeling intensity. These interactions can be established either through a cell-cell contact, involving molecules of the integrin family, or by the release of many polypeptidic factors and/or their soluble receptor chains. These factors can act directly on osteogenic cells and their precursors to control differentiation, formation and functions (matrix formation, mineralization, resorption...). Here, we present the involvement of three groups of cytokines which seem to be of particular importance in bone physiology: interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha) (TNF-alpha)/IL-1, and the more recently known triad osteoprotegerin (OPG)/receptor activator of NF-kappaB (RANK)/RANK ligand (RANKL). The interactions between these three groups are presented within the framework of bone resorption pathophysiology such as tumor associated osteolysis. The central role of the OPG/RANK/RANKL triad is pointed out.

中文翻译：

---

IL-6，RANKL，TNF-α/ IL-1：骨吸收病理生理学的相互关系。

所有成骨细胞（破骨细胞，成骨细胞）均对骨骼重塑做出贡献。它们的细胞相互作用控制着它们的细胞活动和骨重塑强度。这些相互作用可以通过涉及整联蛋白家族分子的细胞间接触或通过释放许多多肽因子和/或其可溶性受体链来建立。这些因素可以直接作用于成骨细胞及其前体，以控制分化，形成和功能（基质形成，矿化，吸收...）。在这里，我们介绍了三组细胞因子的参与，它们似乎在骨骼生理中特别重要：白细胞介素6（IL-6），肿瘤坏死因子-α（TNF-alpha）/ TNF-1 ，以及最近已知的三联骨保护素（OPG）/NF-κB（RANK）/ RANK配体（RANKL）的受体激活剂。这三组之间的相互作用在骨骼吸收病理生理学（例如肿瘤相关的骨溶解）的框架内呈现。指出了OPG / RANK / RANKL三合会的核心作用。