The transforming growth factor-beta (TGF-beta) superfamily of receptors comprises two groups of transmembrane serine-threonine kinase receptors, so called type I, and type II receptors, that are activated following engagement by members of the TGF-beta superfamily of ligands. These events specify diverse downstream responses that are differentially regulated by controlling access and activation of the ligands, their receptors and downstream substrates in different cell types. The purpose of this review is to describe the biochemical properties of these receptors, focusing specifically on the mechanisms regulating receptor/ligand interactions and activation in mammalian cells.

中文翻译：

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受体的转化生长因子-β超家族。

受体的转化生长因子-β（TGF-β）超家族包括两组跨膜丝氨酸-苏氨酸激酶受体，即所谓的I型和II型受体，它们在配体的TGF-β超家族成员参与后被激活。这些事件说明了不同的下游反应，这些反应通过控制配体，它们的受体和不同细胞类型的下游底物的进入和激活而受到不同调节。这篇综述的目的是描述这些受体的生化特性，特别关注调节哺乳动物细胞中受体/配体相互作用和激活的机制。