Recent interest has focused on interactions between natural killer (NK) cells and dendritic cells (DCs). In vitro and in vivo studies have demonstrated various effects of NK-DC interactions, including activation and cytokine production, maturation of DCs and NK-cell lysis of certain autologous DCs. These interactions are important during an immune response in vivo, however, it remains unclear where in the body NK cells and DCs might interact and whether observed in vitro crosstalk between these cell types happens in vivo. We propose evidence for at least two potential locations of in vivo interactions for human NK cells and DCs, including sites of inflammation and lymph nodes.

中文翻译：

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NK细胞与DC的相互作用。

最近的兴趣集中在自然杀伤（NK）细胞和树突状细胞（DC）之间的相互作用。体外和体内研究证明了NK-DC相互作用的各种作用，包括激活和细胞因子产生，DC的成熟以及某些自体DC的NK细胞裂解。这些相互作用在体内免疫反应期间很重要，但是，尚不清楚NK细胞和DC在体内的什么地方相互作用，以及这些细胞类型之间在体外观察到的串扰是否在体内发生。我们提出了至少两个潜在的人体NK细胞和DC体内相互作用的潜在证据，包括炎症部位和淋巴结。