Although inflammatory and immunological reactions protect the host from invasion by microorganisms and eliminate debris at sites of tissue injury, they can also be responsible for significant tissue damage. Thus, regulatory mechanisms that limit damage from an overly exuberant immune response have evolved. It is increasingly apparent that adenosine, a purine nucleoside that is elaborated at injured and inflamed sites, has a central role in the regulation of inflammatory responses and in limiting inflammatory tissue destruction. Adenosine, called a 'retaliatory metabolite' because it is a regulatory autocoid that is generated as a result of cellular injury or stress, interacts with specific G protein-coupled receptors on inflammatory and immune cells to regulate their function. The effects of adenosine, acting at its receptors, on the functions of the cells that mediate innate immune responses, will be reviewed.

中文翻译：

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腺苷：先天免疫的内源性调节剂。

尽管炎症和免疫反应可保护宿主免受微生物侵袭，并消除组织损伤部位的碎屑，但它们也可能导致严重的组织损伤。因此，已经形成了限制由过度旺盛的免疫反应引起的损害的调节机制。越来越明显的是，腺苷是一种在受伤和发炎的部位形成的嘌呤核苷，在调节炎症反应和限制炎症组织破坏中起着核心作用。腺苷被称为“报复性代谢产物”，因为它是细胞损伤或压力产生的调节性类自体体，与炎症和免疫细胞上特定的G蛋白偶联受体相互作用，以调节其功能。腺苷在其受体上的作用，