Although regenerating gene (Reg) protein is reported to have a trophic effect on gastric epithelial cells, its involvement in human gastric diseases is not clear. We have recently shown that both gastrin and gastric mucosal inflammation enhance Reg gene expression in the fundic mucosa in rats. This study was designed to clarify whether Reg protein is involved in Helicobacter pylori-induced gastritis and whether Reg gene expression is linked to serum gastrin levels in this condition. Mongolian gerbils were inoculated with an H. pylori strain isolated from a gastric cancer patient. Four weeks later, some of the gerbils with H. pylori infection were eradicated by lansoprazole, amoxicillin, and clarithromycin. The time courses of changes in Reg gene expression, serum gastrin levels, gastric acidity, and histopathologic factors were examined. Four weeks after H. pylori infection, gastritis started spreading to the fundic mucosa, and gastric acidity started reducing. Serum gastrin levels and Reg mRNA expression in the fundus were significantly increased 6 weeks after infection. Reg mRNA expression in the fundus correlated significantly with both serum gastrin levels and the severity of fundic mucosal inflammation. After H. pylori eradication, serum gastrin levels and fundic mucosal inflammation were normalized, and the increase in Reg mRNA expression was abolished. The Reg gene is associated with hypergastrinemia and fundic mucosal inflammation and may be involved in H. pylori-induced gastritis.

中文翻译：

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幽门螺杆菌感染对蒙古沙鼠再生基因表达与血清胃泌素水平之间联系的影响。

尽管据报道再生基因 (Reg) 蛋白对胃上皮细胞具有营养作用，但其与人类胃病的关系尚不清楚。我们最近表明，胃泌素和胃粘膜炎症都会增强大鼠胃底粘膜中 Reg 基因的表达。本研究旨在阐明 Reg 蛋白是否与幽门螺杆菌引起的胃炎有关，以及 Reg 基因表达是否与这种情况下的血清胃泌素水平有关。蒙古沙鼠接种了从胃癌患者身上分离出的幽门螺杆菌菌株。四个星期后，兰索拉唑、阿莫西林和克拉霉素消灭了一些感染幽门螺杆菌的沙鼠。检查了 Reg 基因表达、血清胃泌素水平、胃酸度和组织病理学因素随时间变化的过程。幽门螺杆菌感染 4 周后，胃炎开始蔓延至胃底粘膜，胃酸度开始降低。感染后 6 周血清胃泌素水平和眼底 Reg mRNA 表达显着增加。眼底中 Reg mRNA 的表达与血清胃泌素水平和胃底粘膜炎症的严重程度显着相关。幽门螺杆菌根除后，血清胃泌素水平和胃底粘膜炎症恢复正常，Reg mRNA 表达的增加被消除。Reg基因与高胃泌素血症和胃底粘膜炎症有关，可能与幽门螺杆菌引起的胃炎有关。感染后 6 周血清胃泌素水平和眼底 Reg mRNA 表达显着增加。眼底中 Reg mRNA 的表达与血清胃泌素水平和胃底粘膜炎症的严重程度显着相关。幽门螺杆菌根除后，血清胃泌素水平和胃底粘膜炎症恢复正常，Reg mRNA 表达的增加被消除。Reg基因与高胃泌素血症和胃底粘膜炎症有关，可能与幽门螺杆菌引起的胃炎有关。感染后 6 周血清胃泌素水平和眼底 Reg mRNA 表达显着增加。眼底中 Reg mRNA 的表达与血清胃泌素水平和胃底粘膜炎症的严重程度显着相关。幽门螺杆菌根除后，血清胃泌素水平和胃底粘膜炎症恢复正常，Reg mRNA 表达的增加被消除。Reg基因与高胃泌素血症和胃底粘膜炎症有关，可能与幽门螺杆菌引起的胃炎有关。并且Reg mRNA表达的增加被废除。Reg基因与高胃泌素血症和胃底粘膜炎症有关，可能与幽门螺杆菌引起的胃炎有关。并且Reg mRNA表达的增加被废除。Reg基因与高胃泌素血症和胃底粘膜炎症有关，可能与幽门螺杆菌引起的胃炎有关。