Active transport and localized translation of the ASH1 mRNA at the bud tip of the budding yeast Saccharomyces cerevisiae is an essential process that is required for the regulation of the mating type switching. ASH1 mRNA localization has been extensively studied over the past few years and the core components of the translocation machinery have been identified. It is composed of four localization elements (zipcodes), within the ASH1 mRNA, and at least three proteins, She1p/Myo4p, She2p and She3p. Whereas the movement of the RNA can be attributed to direct interaction with myosin, the regulation of the RNA expression is less well understood. Recent insights have revealed a role for translation that might have a key function in the regulation of Ash1 protein sorting.

中文翻译：

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酵母中的RNA不对称分布和子/母分化。

ASH1 mRNA在发芽酵母酿酒酵母芽尖的主动转运和局部翻译是调控交配类型转换所必需的基本过程。在过去的几年中，ASH1 mRNA的定位已经得到了广泛的研究，并且已经确定了转运机制的核心组成部分。它由ASH1 mRNA中的四个定位元素（邮政编码）和至少三个蛋白质She1p / Myo4p，She2p和She3p组成。尽管RNA的运动可归因于与肌球蛋白的直接相互作用，但对RNA表达的调控了解得较少。最近的见解揭示了翻译的作用，该作用可能在Ash1蛋白质分选的调控中起关键作用。