Recent insights into the cellular and molecular mechanisms that control the function and regulation of hepatobiliary transport have led to a greater understanding of the physiological significance of bile secretion. Individual carriers for bile acids and other organic anions in both liver and intestine have now been cloned from several species. In addition, complex networks of signals that regulate key enzymes and membrane transporters located in cells that participate in the metabolism or transport of biliary constituents are being unraveled. This knowledge has major implications for the pathogenesis of cholestatic liver diseases. Here, we review recent information on molecular aspects of hepatobiliary secretory function and its regulation in cholestasis. Potential implications of this knowledge for the design of new therapies of cholestatic disorders are also discussed.

中文翻译：

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胆汁形成和胆汁淤积的分子方面。

对控制肝胆运输功能和调节的细胞和分子机制的最新见解使人们对胆汁分泌的生理意义有了更深入的了解。现在已经从几种物种中克隆了胆汁酸和肝和肠中其他有机阴离子的单独载体。另外，调节参与参与胆汁成分的代谢或转运的细胞中的关键酶和膜转运蛋白的信号复杂网络也正在研究中。该知识对胆汁淤积性肝病的发病机理具有重要意义。在这里，我们审查有关肝胆分泌功能的分子方面及其在胆汁淤积中的调节的最新信息。