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Olefin metathesis in glycobiology: new routes towards diverse neoglycoconjugates.
Current Opinion in Chemical Biology ( IF 6.9 ) Pub Date : 2003-12-04 , DOI: 10.1016/j.cbpa.2003.10.009
Michiel A Leeuwenburgh 1 , Gijsbert A van der Marel , Herman S Overkleeft
Affiliation  

This report provides a historical overview of the implementation of olefin metathesis in carbohydrate chemistry, with the emphasis on the construction of neoglycoconjugates. The current state-of-the-art in catalyst design allows the preparation of carbohydrate-containing molecules with great structural and functional diversity. Recent examples of complex neoglycoconjugates, including glycopolymers, glycoclusters, glycopeptide and glycolipid analogues are highlighted. Finally, future perspectives in the scope of olefin metathesis mediated neoglycoconjugate synthesis are discussed.

中文翻译:

糖生物学中的烯烃复分解:通往新的新糖缀合物的新途径。

该报告提供了在碳水化合物化学中实施烯烃复分解的历史综述,重点是新糖缀合物的构建。当前催化剂设计的最新技术允许制备具有很大结构和功能多样性的含碳水化合物分子。复杂的新糖缀合物的最新实例包括糖聚合物,糖簇,糖肽和糖脂类似物。最后,讨论了在烯烃复分解介导的新糖缀合物合成范围内的未来观点。
更新日期:2019-11-01
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