Cytokine signaling is dependent on the activation of intracellular molecules, including JAKs (Janus family kinases) and STATs (signal transducers and activators of transcription). Since the discovery of the SOCS (suppressor of cytokine signaling) family molecules in 1997, extensive investigation of these molecules has given important insights into the as yet unclarified regulatory mechanisms of cytokine signaling. Recent gene targeting analyses of SOCS molecules have revealed that they do indeed have essential roles in vivo (more specific than those expected from overexpression studies in vitro) in the negative regulation of various cytokines. Moreover, consistent with the pathological actions of cytokines in human diseases, recent lines of evidence also indicate that SOCS molecules are implicated in autoimmunity, allergy and cancers.

中文翻译：

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SOCS家族分子对细胞因子信号传导的调节。

细胞因子信号传导依赖于细胞内分子的激活，包括JAK（Janus家族激酶）和STATs（信号转导子和转录激活子）。自从1997年发现SOCS（细胞因子信号转导抑制剂）家族分子以来，对这些分子的广泛研究为细胞因子信号转导的调控机制提供了重要的见识。最近对SOCS分子进行的基因靶向分析表明，它们确实在体内对各种细胞因子的负调节起着至关重要的作用（比体外过表达研究所预期的更具特异性）。此外，与细胞因子在人类疾病中的病理作用一致，最近的证据还表明，SOCS分子与自身免疫，过敏和癌症有关。