Dendritic cells (DCs) take up antigens using antigen receptors that can be divided into three major classes: C-type lectins, integrins and Fc receptors. These receptors facilitate effective presentation of MHC-peptide complexes to T cells, resulting in the induction of immune responses. However, we discuss recent evidence that some receptors also cause induction of tolerance. Signaling motifs within the receptors either block maturation of DCs or induce signals that render DCs tolerogenic. These DCs then either induce regulatory T cells or cause deletion of effector T cells, resulting in the induction of tolerance. Antigen receptors expressed by DCs might therefore have an important role in the induction and maintenance of peripheral tolerance.

中文翻译：

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耐受DC的诱导：“你就是你吃的东西”。

树突状细胞（DC）使用可分为三大类的抗原受体吸收抗原：C型凝集素，整联蛋白和Fc受体。这些受体促进了MHC-肽复合物向T细胞的有效呈递，导致了免疫反应的诱导。但是，我们讨论了最近的证据，即某些受体也会引起耐受性。受体内的信号基序要么阻断DC的成熟，要么诱导使DC具有致耐受性的信号。这些DC然后诱导调节性T细胞或引起效应T细胞的缺失，从而导致耐受性的诱导。DCs表达的抗原受体因此可能在诱导和维持外周耐受中起重要作用。