The function mediated by the engagement of the lymphocyte activation gene-3 (LAG-3, CD223) receptor expressed on activated T cells by its MHC class II ligand has remained enigmatic, partly owing to discrepancies between published results in human and mouse systems. Recent studies in mice have reconciled previous interpretations and clearly show that, as in human cells, LAG-3 negatively regulates T-cell function and homeostasis. As a soluble molecule, LAG-3 activates antigen-presenting cells through MHC class II signalling, leading to increased antigen-specific T-cell responses in vivo.

中文翻译：

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LAG-3：T细胞和DC反应的调节剂及其在治疗性疫苗接种中的用途。

通过其MHC II类配体在活化的T细胞上表达的淋巴细胞活化基因3（LAG-3，CD223）受体的参与介导的功能仍然是令人迷惑的，部分是由于在人和小鼠系统中发表的结果之间存在差异。最近在小鼠中进行的研究与先前的解释相符，并清楚地表明，与人类细胞一样，LAG-3负调节T细胞功能和体内平衡。作为一种可溶性分子，LAG-3通过II类MHC信号传导激活抗原呈递细胞，从而导致体内抗原特异性T细胞应答增加。