当前位置:
X-MOL 学术
›
Trends Immunol.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Tetraspanins: molecular organisers of the leukocyte surface.
Trends in Immunology ( IF 13.1 ) Pub Date : 2003-11-05 , DOI: 10.1016/j.it.2003.09.011 Jacqueline M Tarrant 1 , Lorraine Robb , Annemiek B van Spriel , Mark D Wright
Trends in Immunology ( IF 13.1 ) Pub Date : 2003-11-05 , DOI: 10.1016/j.it.2003.09.011 Jacqueline M Tarrant 1 , Lorraine Robb , Annemiek B van Spriel , Mark D Wright
Affiliation
Tetraspanins are a large superfamily of cell surface membrane proteins characterised by their four transmembrane domains. They are expressed in a wide variety of cell types and have functional roles in processes, such as cellular adhesion, motility, activation and tumour invasion. Leukocytes express =20 tetraspanin proteins on their surface. Tetraspanins have an exceptional ability to interact with a diverse array of important proteins, such as integrins, immunoreceptors and signalling molecules. They are thought to organise a novel type of cell surface membrane microdomain, which in leukocytes functions to regulate activation, motility and antigen presentation. The importance of tetraspanin microdomains in immunity is highlighted by the perturbations in the immune system observed in tetraspanin-deficient mice.
中文翻译:
四跨膜蛋白:白细胞表面的分子组织器。
四跨膜蛋白是细胞表面膜蛋白的大超家族,其特征在于它们的四个跨膜结构域。它们在各种各样的细胞类型中表达,并且在过程中具有功能性作用,例如细胞粘附,运动性,活化和肿瘤侵袭。白细胞表达
更新日期:2019-11-01
中文翻译:
四跨膜蛋白:白细胞表面的分子组织器。
四跨膜蛋白是细胞表面膜蛋白的大超家族,其特征在于它们的四个跨膜结构域。它们在各种各样的细胞类型中表达,并且在过程中具有功能性作用,例如细胞粘附,运动性,活化和肿瘤侵袭。白细胞表达