Vitamin-A is essential for growth and development of cells and tissues. In its active form, retinoic acid, it controls the regular differentiation as a ligand for retinoic acid receptors (RAR, RXR) and is involved in the integration (gap junction formation) of cell formations [Nature 37 (1994) 528; International Review of Cytology. San Diego Academic Press, 1-31]. Vitamin-A plays a substantial role, especially in the respiratory epithelium and the lung. During moderate vitamin-A-deficiency, the incidence for diseases of the respiratory tract is considerably increased and repeated respiratory infections can be influenced therapeutically by a moderate vitamin-A-supplementation [Aust. Paediatr. J. 22 (1986) 95; Lancet 338 (1991) 67]. In addition to the importance of the vitamin for the lung function, vitamin-A is also responsible for the development of many tissues and cells as well as for the embryonic lung development. Recent studies proved that the control occurs by different expressions of retinoid receptors as well as by time-dependent changes of the vitamin-A-metabolism respectively via cellular vitamin-A-binding proteins (CRBP: cytoplasmatic retinol binding protein; CRABP: cytoplasmatic retinoic acid binding protein).

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维生素A对肺功能和发育的重要性。

维生素A对细胞和组织的生长和发育至关重要。在其活性形式视黄酸中，它作为视黄酸受体（RAR，RXR）的配体控制着规律的分化，并参与细胞形成的整合（间隙连接形成）[Nature 37（1994）528； 5（2）：2]。细胞学国际评论。圣地亚哥学术出版社，1-31]。维生素A发挥着重要作用，尤其是在呼吸道上皮和肺中。在中度维生素A缺乏症期间，呼吸道疾病的发生率显着增加，并且中度补充维生素A可以治疗重复性呼吸道感染[Aust。儿科。J.22（1986）95; Lancet 338（1991）67]。除了维生素对肺功能的重要性外，维生素A还负责许多组织和细胞的发育以及胚胎肺的发育。最近的研究证明，这种控制是通过类维生素A受体的不同表达以及分别通过细胞维生素A结合蛋白（CRBP：胞质视黄醇结合蛋白； CRABP：胞质视黄酸）随时间变化的维生素A代谢而发生的。结合蛋白）。