Neurotrophins are growth factors that exert multiple actions on neuronal and nonneuronal cells. Neurotrophin receptors are expressed on central and peripheral neurons, lymphocytes, monocytes, mast cells, and fibroblasts. In accordance with the distribution of their receptors, neurotrophins control the development and function of neurons and regulate inflammatory processes. Production of neurotrophins is altered in asthma, lung cancer, and pulmonary fibrosis. Evidence from animal models has implicated nerve growth factor (NGF) as a mediator of pulmonary inflammation, bronchoconstriction, and airway hyperreactivity, all of which are hallmarks of asthma. NGF regulates the growth of lung tumor cells and cultured lung fibroblasts. Thus neurotrophins, particularly NGF, are candidate molecules for regulating disease processes in asthma, lung cancer, and pulmonary fibrosis.

中文翻译：

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神经营养蛋白和肺部疾病。

神经营养蛋白是在神经元和非神经元细胞上发挥多种作用的生长因子。神经营养蛋白受体在中枢和外周神经元，淋巴细胞，单核细胞，肥大细胞和成纤维细胞上表达。根据其受体的分布，神经营养蛋白控制神经元的发育和功能并调节炎症过程。在哮喘，肺癌和肺纤维化中，神经营养蛋白的产生发生了变化。动物模型的证据表明，神经生长因子（NGF）是肺部炎症，支气管收缩和气道高反应性的介质，所有这些都是哮喘的标志。NGF调节肺肿瘤细胞和培养的肺成纤维细胞的生长。因此，神经营养蛋白，尤其是NGF，是调节哮喘，肺癌，