The Src homology domain 2 (SH2)-containing tyrosine phosphatase-1 (SHP-1) has been implicated in the regulation of differentiation, proliferation, and activation of hematopoietic cells. In this review, we discuss the potential role of SHP-1 in modulating apoptosis pathways in neutrophils. Low enzymatic SHP-1 was associated with increased neutrophil survival in vitro and SHP-1-deficient mice were reported to develop severe neutrophilic inflammatory responses. In contrast, high expression of this phosphatase was observed in neutropenic patients. Moreover, when neutrophils were exposed to Fas ligand, TNF-alpha, or TRAIL, the anti-apoptotic effects of granulocyte-macrophage colony-stimulating factor (GM-CSF), granulocyte colony-stimulating factor (G-CSF), or IFN-gamma were blocked, most likely by SHP-1-mediated inactivation of anti-apoptotic signaling molecules. In summary, the current available data point to an important role of SHP-1 in the regulation of neutrophil apoptosis.

中文翻译：

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SHP-1：中性粒细胞凋亡的调节剂。

含Src同源域2（SH2）的酪氨酸磷酸酶-1（SHP-1）已牵涉调节造血细胞的分化，增殖和活化。在这篇综述中，我们讨论了SHP-1在调节中性粒细胞凋亡途径中的潜在作用。低酶促SHP-1与体外嗜中性粒细胞存活增加有关，据报道，SHP-1缺陷小鼠会出现严重的嗜中性粒细胞炎症反应。相反，在中性粒细胞减少症患者中观察到该磷酸酶的高表达。此外，当嗜中性粒细胞暴露于Fas配体，TNF-α或TRAIL时，粒细胞-巨噬细胞集落刺激因子（GM-CSF），粒细胞集落刺激因子（G-CSF）或IFN-α的抗凋亡作用伽玛被阻止，最有可能是由SHP-1介导的抗凋亡信号分子失活。总而言之，当前可获得的数据表明SHP-1在中性粒细胞凋亡的调节中起着重要作用。