CD95/CD95L mediated apoptosis is an important mechanism of immune homeostasis. It is instrumental for termination of an immune response and mainly be involved in peripheral tolerance. Dysregulation of the CD95/CD95L system leads to severe diseases. In this review, we present a survey of the role of the CD95/CD95L system in the immune system and, particularly, focus on the signals and transcription factors (NF-AT, Egr, NF-kappaB, AP-1, c-Myc, Nur77, IRFs, SP-1, ALG-4, ROR(gamma)t, and CIITA) involved in CD95L expression. It should also be evident from this review that a profound insight into the molecular mechanisms of CD95L activation should allow to explore potential therapeutic means to treat CD95/CD95L-dependent diseases.

中文翻译：

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CD95（APO-1 / Fas）配体在免疫系统中的功能和调节。

CD95 / CD95L介导的细胞凋亡是免疫稳态的重要机制。它有助于终止免疫反应，主要参与外周耐受。CD95 / CD95L系统失调会导致严重疾病。在这篇综述中，我们对CD95 / CD95L系统在免疫系统中的作用进行了调查，特别是着眼于信号和转录因子（NF-AT，Egr，NF-kappaB，AP-1，c-Myc ，Nur77，IRF，SP-1，ALG-4，RORγt和CIITA）参与CD95L表达。从这篇评论中也应该清楚地看到，对CD95L激活的分子机制的深刻洞察应该允许探索治疗CD95 / CD95L依赖性疾病的潜在治疗手段。