The herpesvirus Human Cytomegalovirus (HCMV) is an important opportunistic infection in recipients of allogeneic haemopoietic stem cell transplants, in whom HCMV-specific CD8+ and CD4+ T-cell responses are impaired. The nature of the HCMV-specific T-cell response in healthy virus carriers has been characterised in detail. High frequencies of circulating CD8+ T-cells that recognise defined viral peptides are maintained for years, and include individual CD8+ clones that have undergone extensive clonal expansion and phenotypic diversification in vivo. Following stem cell transplantation, the kinetics of HCMV-specific CD8+ T-cell reconstitution in the recipient are related to the presence or absence of antigen-experienced CD8+ T-cells transferred via the allograft, and to the presence of the virus in the recipient. We discuss recent progress in our understanding of HCMV-specific immunity in healthy virus carriers and in recipients after alloSCT.

中文翻译：

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造血干细胞移植后的人类巨细胞病毒特异性免疫。

疱疹病毒人巨细胞病毒（HCMV）是异基因造血干细胞移植受者的一种重要机会性感染，其中HCMV特异性CD8 +和CD4 + T细胞反应受到损害。健康病毒载体中HCMV特异性T细胞反应的性质已得到详细描述。识别定义的病毒肽的循环CD8 + T细胞的高频率已经维持了多年，并且包括在体内经历了广泛的克隆扩增和表型多样化的单个CD8 +克隆。干细胞移植后，受体中HCMV特异性CD8 + T细胞重构的动力学与通过同种异体移植转移的抗原经历的CD8 + T细胞的存在与否以及受体中病毒的存在有关。