The hematopoietic system generally has reserve sufficient to tolerate significant insult and regenerative capacity to overcome most damage due to infectious agents. However, HIV infection results in a progressive decline in hematopoietic function and even in the context of potent, anti-retroviral therapy is able to only incompletely reconstitute immune function. The ability of the immune system to respond to HIV itself remains compromised, a defect that leaves infected individuals with a lifelong dependence on medications. The capability of stem cells and the thymus to restore function and their limitations in the context of HIV infection are discussed in this review.

中文翻译：

---

艾滋病中的干细胞和免疫重建。

造血系统通常具有足够的储备以耐受显着的侵害和再生能力，以克服由于传染原引起的大多数损害。但是，HIV感染会导致造血功能逐渐下降，即使在有效的抗逆转录病毒疗法的情况下也只能不完全恢复免疫功能。免疫系统对HIV自身反应的能力仍然受到损害，这种缺陷使受感染的人终生依赖药物治疗。在这篇综述中讨论了干细胞和胸腺恢复功能的能力及其在HIV感染情况下的局限性。