Celiac disease (CD) is an autoimmune enteropathy triggered by the ingestion of gluten in susceptible individuals, and is one of the most frequent genetically based diseases, with a prevalence of 1:200 in the general population. The association between CD and connective tissue diseases (CTD) and autoimmune diseases of the digestive tract (DT) has been described in several case reports but in few extensive studies, with varying prevalence. A high rate of false positive results were observed when low specific tests, such as the anti-gliadin and the guinea pig tissue transglutaminase (tTG) antibody assays were used. In a study of 400 patients with CTD and 218 with autoimmune DT disease, tested for IgA and IgG anti-tTG using the more specific human recombinant antigen, 12 cases (1.9%) of anti-tTG antibody positivity were found, but only 2 (0.3%) were confirmed as affected by CD following small bowel biopsy. Most of the patients testing false positive had primary biliary cirrhosis. In this short review we describe the association between CD and CTD, inflammatory bowel disease and primary biliary cirrhosis, with special emphasis on the diagnostic accuracy of CD antibody assays.

中文翻译：

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腹腔疾病与结缔组织疾病和消化道自身免疫疾病的关联。

乳糜泻（CD）是易感个体摄入麸质而引发的自身免疫性肠病，是最常见的遗传性疾病之一，在一般人群中患病率为1：200。CD与结缔组织疾病（CTD）和消化道自身免疫性疾病（DT）之间的关系已在几例病例报告中进行了描述，但在几项广泛的研究中，其流行程度各不相同。当使用低特异性试验（例如抗麦醇溶蛋白和豚鼠组织转谷氨酰胺酶（tTG）抗体试验）时，观察到较高的假阳性结果率。在一项针对400名CTD患者和218名自身免疫性DT疾病患者的研究中，使用更特异性的人类重组抗原检测了IgA和IgG抗tTG，发现12例（1.9％）抗tTG抗体阳性，但只有2例（ 0。小肠活检后证实3％受CD影响。大多数检测为假阳性的患者患有原发性胆汁性肝硬化。在这篇简短的综述中，我们描述了CD与CTD，炎性肠病和原发性胆汁性肝硬化之间的关联，并特别着重于CD抗体测定的诊断准确性。