Kawasaki disease (KD) is a febrile systemic vasculitis complicated by coronary and peripheral arterial aneurysms in 20-35% of untreated patients. It is reported as the commonest cause of acquired heart disease in children in developed countries, and may be a risk for adult ischaemic heart disease. Although KD has been reported all over the world, it is overexpressed among Asian populations, especially Japanese. The disease pathogenesis is still unknown and several theories have been proposed, including the possibility of an infection by a toxin-secreting microorganism and of a superantigen-driven process. Despite numerous efforts there is still no diagnostic test available for KD, and the diagnosis is based on clinical criteria after the exclusion of other diseases presenting with high persistent fever. Prompt diagnosis is critical, since the early administration of intravenous immunoglobulins and aspirin reduces the rate of coronary abnormalities to less than 5% of patients.

中文翻译：

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川崎病的最新动态。

川崎病（KD）是一种热性系统性血管炎，在20％至35％的未治疗患者中并发冠状动脉和周围动脉瘤。据报道，它是发达国家儿童中获得性心脏病的最常见原因，并且可能是成人缺血性心脏病的风险。尽管KD在世界各地都有报道，但在亚洲人群中，特别是在日本人中，KD的表达过高。该疾病的发病机理仍是未知的，并且已经提出了几种理论，包括可能由分泌毒素的微生物感染和由超抗原驱动的过程。尽管付出了许多努力，但仍没有可用于KD的诊断测试，并且在排除表现为持续高烧的其他疾病后，诊断是基于临床标准。及时诊断至关重要