The major envelope protein of the hepatitis B virus (HBV), the HBsAg, constitutes the current preventative vaccine, which represents the first subunit viral vaccine developed. The genetics of the immune response to HBsAg has been extensively studied both in humans and mice. Murine studies begun over 20 years ago indicated that at least two MHC class II and one MHC class III genes regulate anti-HBs immune responses. Additional MHC-linked genes influence the immune responses to the higher molecular weight (pre-S) components of the HBV envelope. The murine studies predicted even more complex MHC gene regulation of human immune responses to the HBsAg and that complexity certainly has been demonstrated during the ensuing years. This brief review is an attempt to summarize our current understanding of the MHC genes that influence the immune response to the HBsAg and possible mechanisms of action.

中文翻译：

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HBsAg疫苗接种反应的免疫遗传学。

乙型肝炎病毒（HBV）的主要包膜蛋白HBsAg构成了目前的预防性疫苗，代表了首个开发的亚单位病毒疫苗。HBsAg免疫应答的遗传学已在人类和小鼠中进行了广泛的研究。超过20年前开始的小鼠研究表明，至少有两个II类MHC和一个III类MHC基因调节抗HBs免疫反应。其他与MHC相关的基因影响对HBV包膜的较高分子量（pre-S）成分的免疫反应。鼠类研究预测，人类对HBsAg的免疫反应的MHC基因调控更为复杂，并且在随后的几年中肯定已经证明了其复杂性。