The molecular mechanisms which control the transcription of growth factor genes underlie such diverse biological processes as embryonic development, cellular differentiation and wound healing. Moreover, disruption of these controls is implicated in the development and progression of a wide variety of human diseases, including cancer, atherosclerosis and fibrotic disease. This review highlights progress made in the study of the gene encoding platelet-derived growth factor A-chain (PDGF-A) from the perspective of its normal patterns of expression, as well as possible mechanisms leading to dysregulation and disease. A particular focus has been placed on the identification and characterization of specific DNA elements, DNA-binding proteins and other aspects of transcriptional regulation involved in activation and repression of the human PDGF-A promoter.

中文翻译：

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血小板衍生的生长因子A链基因的转录。

控制生长因子基因转录的分子机制是胚胎发育，细胞分化和伤口愈合等多种生物学过程的基础。此外，这些控制的破坏与多种人类疾病的发展和进展有关，包括癌症，动脉粥样硬化和纤维化疾病。这篇综述从其正常表达模式以及导致失调和疾病的可能机制的角度突出了研究编码血小板源性生长因子A链（PDGF-A）的基因的研究进展。特别关注的是特定DNA元素的鉴定和表征，