CCL20, alternatively named liver and activation-regulated chemokine (LARC), macrophage inflammatory protein-3alpha (MIP-3alpha) or Exodus-1, is the only chemokine known to interact with CC chemokine receptor 6 (CCR6), a property shared with the antimicrobial beta-defensins. The ligand-receptor pair CCL20-CCR6 is responsible for the chemoattraction of immature dendritic cells (DC), effector/memory T-cells and B-cells and plays a role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and rheumatoid arthritis. In this review, the discovery, the gene and protein structure, the in vitro biological activities, the cell and inducer specific expression and the tissue distribution of CCL20 and CCR6 are discussed.

中文翻译：

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CC趋化因子CCL20及其受体CCR6。

CCL20，也称为肝脏和活化调节趋化因子（LARC），巨噬细胞炎性蛋白3alpha（MIP-3alpha）或出埃及记1，是已知与CC趋化因子受体6（CCR6）相互作用的唯一趋化因子。抗菌β-防御素。配体-受体对CCL20-CCR6负责未成熟树突状细胞（DC），效应子/记忆性T细胞和B细胞的化学引诱作用，并在稳态和炎性条件下以及在皮肤和粘膜表面起作用病理包括癌症和类风湿关节炎。本文综述了CCL20和CCR6的发现，基因和蛋白质结构，体外生物学活性，细胞和诱导物的特异性表达以及组织分布。