Nerve Growth Factor (NGF), that was originally discovered for its properties of stimulating growth and differentiation of neurons, is now also considered responsible for several activities in the immune system and beyond. Mast cells and eosinophils, key cells of allergic inflammation, are a source of NGF and are influenced by it. These observations have prompted studies on NGF in allergy and tissue repair. Recent evidences link NGF and these two processes. While NGF is clearly a new tool in the management of untreatable ulcers, its role in allergic inflammation, although appearing to be pro-inflammatory, is still not clearly defined.

中文翻译：

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关于神经生长因子参与过敏性炎症和纤维化的新见解。

神经生长因子（NGF）最初是由于其刺激神经元生长和分化的特性而被发现的，现在也被认为与免疫系统中的多种活动有关。肥大细胞和嗜酸性粒细胞是过敏性炎症的关键细胞，是NGF的来源，并受其影响。这些观察促使对NGF在过敏和组织修复中的研究。最近的证据将NGF与这两个过程联系在一起。尽管NGF显然是治疗无法治愈的溃疡的一种新工具，但它在变应性炎症中的作用虽然看起来是促炎性的，但仍不清楚。