This present research work reports the possible effects and the underlying mechanism of atorvastatin on survival rate and cognitive disorders after sepsis. Sepsis is a life-threatening dysfunction that arises when the body's response to infection causes injury to its own tissues and organs. Diffuse sepsis was induced by cecal ligation and puncture surgery (CLP) in ICR mice. 0.2 mg/kg body weight of atorvastatin was administrated intraperitoneally at 12 h before surgery. The survival of mice was calculated 24 h, 48 h, 72 h, and 96 h after CLP surgery. Two weeks later, open-field test and Morris water maze test were conducted to evaluate the protective effect of atorvastatin. Inflammatory cytokines in plasma, oxidative stress parameters, number of astrocytes, and neuronal cell deaths in the CA3 region of the hippocampus were examined using enzyme-linked immunosorbent assay (ELISA) and immunohistochemistry. The results indicate that pretreatment with atorvastatin can increase survival percentage and improve cognitive function. Atorvastatin reversed all these alterations in parallel with a decrease in circulating levels of cytokines (IL-1β, IL-4, IL-6, and TNF-α) in plasma, inhibited the activities of oxidative stress parameters (lower TBARS levels, ratio of GSH/GSSH, and activities of SOD and CAT), enhanced the activity of citrate synthase in brain, and reduced the number of astrocytes and neuronal cell deaths in CA3 region of hippocampus. Overall, our results indicated that atorvastatin exhibited protective effects on survival rate and cognitive disorders after sepsis by inhibiting the release of inflammatory cytokines, oxidative stress, and neuronal apoptosis in brain tissue.

中文翻译：

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阿托伐他汀通过恢复海马中的炎症细胞因子，氧化应激和神经元凋亡来减轻败血症后的认知障碍。

本研究工作报告了阿托伐他汀对败血症后存活率和认知障碍的可能作用及其潜在机制。败血症是一种威胁生命的功能障碍，当人体对感染的反应导致其自身组织和器官受伤时，就会出现败血症。盲肠结扎和穿刺手术（CLP）在ICR小鼠中诱发弥漫性败血症。在手术前12小时腹膜内给予0.2mg / kg体重的阿托伐他汀。CLP手术后24小时，48小时，72小时和96小时计算小鼠的存活率。两周后，进行了野外试验和莫里斯水迷宫试验，以评估阿托伐他汀的保护作用。血浆中的炎性细胞因子，氧化应激参数，星形胶质细胞的数量，使用酶联免疫吸附测定（ELISA）和免疫组化方法检测海马CA3区神经元细胞死亡。结果表明，阿托伐他汀预处理可以提高生存率，改善认知功能。阿托伐他汀逆转了所有这些改变，同时血浆中循环细胞因子（IL-1β，IL-4，IL-6和TNF-α）的水平降低，抑制了氧化应激参数的活性（较低的TBARS水平， GSH / GSSH以及SOD和CAT的活性）增强了脑中柠檬酸合酶的活性，并减少了海马CA3区星形胶质细胞的数量和神经元细胞的死亡。总体，