General physicochemical properties of the vascular grafts (VGs) produced from the solutions of Tecoflex (Tec) with gelatin (GL) and bivalirudin (BV) by electrospinning are studied. The electrospun VGs of Tec-GL-BV and expanded polytetrafluoroethylene (e-PTFE) implanted in the abdominal aorta of 36 Wistar rats have been observed over different time intervals up to 24 weeks. A comparison shows that 94.5% of the Tec-GL-BV VGs and only 66.6% of e-PTFE VGs (р = 0.0438) are free of occlusions after a 6 month implantation. At the intermediate observation points, Tec-GL-BV VGs demonstrate severe neovascularization of the VG neoadventitial layer as compared with e-PTFE grafts. A histological examination demonstrates a small thickness of the neointima layer and a low level of calcification in Tec-GL-BV VGs as compared with the control grafts. Thus, polyurethane-based protein-enriched VGs have certain advantages over e-PTFE VGs, suggesting their utility in clinical studies.

中文翻译：

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电纺基于聚氨酯的血管移植物：体内的理化性质和功能。

研究了Tecoflex（Tec）与明胶（GL）和bivalirudin（BV）溶液通过静电纺丝生产的血管移植物（VG）的一般理化性质。在长达24周的不同时间间隔内，观察到了植入到36只Wistar大鼠腹主动脉中的Tec-GL-BV和膨化聚四氟乙烯（e-PTFE）的静电纺丝VG。比较显示，植入6个月后，有94.5％的Tec-GL-BV VG和仅66.6％的e-PTFE VG（р= 0.0438）没有阻塞。在中间观察点，与e-PTFE移植物相比，Tec-GL-BV VGs表现出VG新外膜层的严重新血管形成。组织学检查显示与对照移植物相比，Tec-GL-BV VGs的新内膜层厚度小且钙化程度低。从而，