The goal of this research was to promote the bioactivity and osteogenic characteristics of polyvinylidene fluoride(PVDF) fibrous membrane, while preserving its piezoelectric property for bone regeneration. In this regard, core-shell fibrous membrane of PVDF-Ba0.9Ca0.1TiO3/polyvinyl alcohol(PVA) was developed via emulsion electrospinning approach. While PVA was in the outer layer of fibers with thickness of 53 ± 18 nm, the Ba0.9Ca0.1TiO3 nanoparticles was uniformly dispersed in the PVDF core. The formation of PVA shell resulted in significant improvement of its hydrophilicity (3 times) and degradation rate, while piezoelectricity did noticeably modulate. In addition, incorporation of Ba0.9Ca0.1TiO3 nanopowder remarkably improved bioactivity, protein adsorption and mechanical properties of PVDF/PVA fibrous membranes. Finally, the osteogenic differentiation of mesenchymal stem cells on the nanocomposite fibrous membranes, in the absence of osteogenic supplements, was also observed. Overall, the results confirmed the promising potential of PVDF-Ba0.9Ca0.1TiO3/PVA fibrous membrane containing 1-2 wt% nanopowder for bone regeneration.

中文翻译：

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PVDF-Ba0.9Ca0.1TiO3 / PVA的核壳纤维膜具有成骨性和压电性，可促进骨再生。

这项研究的目的是促进聚偏二氟乙烯（PVDF）纤维膜的生物活性和成骨特性，同时保留其压电特性以促进骨骼再生。为此，通过乳液静电纺丝技术开发了PVDF-Ba0.9Ca0.1TiO3 /聚乙烯醇（PVA）的核壳纤维膜。当PVA位于厚度为53±18 nm的纤维外层时，Ba0.9Ca0.1TiO3纳米粒子均匀分散在PVDF芯中。PVA壳的形成导致其亲水性（3倍）和降解率显着提高，而压电性确实有明显的调节作用。此外，掺入Ba0.9Ca0.1TiO3纳米粉可显着提高PVDF / PVA纤维膜的生物活性，蛋白质吸附和机械性能。最后，在没有成骨补充剂的情况下，还观察到了纳米复合纤维膜上间充质干细胞的成骨分化。总体而言，结果证实了含有1-2 wt％纳米粉的PVDF-Ba0.9Ca0.1TiO3 / PVA纤维膜对于骨再生具有广阔的前景。