Background: The gene programmed cell death 5 (PDCD5) has recently been characterized as a tumor suppressor gene and is believed to be an important prognostic cancer marker; it is frequently involved in neoplastic transformation and apoptosis of tumor cells. Several studies have demonstrated a decrease or loss of expression of PDCD5 in certain tumors. However, the relevance of PDCD5 expression in human osteoclastoma and its clinicopathological significance have not been extensively studied. Methods: The aim of this study was to explore the relative transcriptional and translational expression levels of PDCD5 in 79 osteoclastoma samples using multi-modal methods of analysis. Results: Our findings showed that 52% (15/29) of osteoclastoma cases exhibited reduced PDCD5 expression at the transcriptional level, and 56% (44/79) exhibited lower PDCD5 expression at the protein level, when compared with nontumor tissue. In addition, the statistical significance of the altered PDCD5 protein expression was examined using the Campanacci grading system for osteoclastoma. More importantly, the decreased expression at the translational level was observed to have a negative association with the Ki-67 staining index. Conclusion: Based on these findings, abnormal PDCD5 expression might be an important biomarker in human osteoclastoma and may contribute to tumor progression and malignant cell proliferation.

中文翻译：

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破骨细胞瘤中肿瘤抑制基因PDCD5表达降低的临床病理学意义。

背景：基因编程性细胞死亡5（PDCD5）最近已被表征为抑癌基因，被认为是重要的预后癌症标志物。它经常参与肿瘤细胞的肿瘤转化和凋亡。几项研究表明，PDCD5在某些肿瘤中表达的降低或丧失。然而，PDCD5表达在人类破骨细胞瘤中的相关性及其临床病理意义尚未得到广泛研究。方法：本研究的目的是使用多模式分析方法探讨79个破骨细胞瘤样品中PDCD5的相对转录和翻译表达水平。结果：我们的研究结果显示，破骨细胞瘤病例中有52％（15/29）在转录水平上表现出PDCD5表达降低，与非肿瘤组织相比，有56％（44/79）的人PDCD5蛋白水平低。另外，使用Campanacci分级系统对破骨细胞瘤检查了PDCD5蛋白表达改变的统计学意义。更重要的是，观察到翻译水平表达的降低与Ki-67染色指数负相关。结论：基于这些发现，PDCD5异常表达可能是人类破骨细胞瘤的重要生物标志物，并可能有助于肿瘤进展和恶性细胞增殖。观察到翻译水平降低的表达与Ki-67染色指数负相关。结论：基于这些发现，PDCD5异常表达可能是人类破骨细胞瘤的重要生物标志物，可能有助于肿瘤进展和恶性细胞增殖。观察到翻译水平降低的表达与Ki-67染色指数负相关。结论：基于这些发现，PDCD5异常表达可能是人类破骨细胞瘤的重要生物标志物，可能有助于肿瘤进展和恶性细胞增殖。