Cytoskeletal disruption is one of the distinguishing characteristics of the vulnerable neurons in Alzheimer disease (AD). It has been suggested that these cytoskeletal changes occur secondarily to covalent modifications of the protein components. Despite the abundance and probable importance of these changes, there has been very little data regarding the identity of the modified proteins or the precise chemistry of the modifications. Here we review a specific type of modification, namely carbonylation of proteins, which has been shown to be a common result of cellular oxidative stress. Hopefully, the following discussion will help elucidate the relationship between oxidative stress, protein modification and the pathogenesis of AD.

中文翻译：

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羟炔醛，有毒羰基和阿尔茨海默氏病。

细胞骨架破坏是阿尔茨海默病（AD）中脆弱神经元的显着特征之一。已经提出这些细胞骨架的改变是继蛋白质成分的共价修饰之后发生的。尽管这些变化有很多而且很重要，但是关于修饰蛋白的身份或修饰的精确化学的数据很少。在这里，我们审查一种特定类型的修饰，即蛋白质的羰基化，这已被证明是细胞氧化应激的常见结果。希望下面的讨论将有助于阐明氧化应激，蛋白质修饰与AD发病机理之间的关系。