Therapy of ocular immune-mediated diseases has changed dramatically over the past two decades. Although a variety of non-specific immunosuppressive agents are introduced, with advances in cell biology a number of more specific therapeutic options will become available. Gene therapy has the potential to interfere with the immune response at different steps modulating the microenvironment of the eye. In this chapter we focus attention on the most promising candidate genes for gene therapy in ocular immune diseases. Furthermore, we outline the current techniques for delivering genes of interest with their potential merits and drawbacks in the field of ophthalmology. Many of these approaches are still in early phases of study for the treatment of clinical relevant immune-mediated diseases.

中文翻译：

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基因治疗在免疫介导的眼部疾病中。

在过去的二十年中，眼部免疫介导的疾病的治疗发生了巨大变化。尽管引入了多种非特异性免疫抑制剂，但是随着细胞生物学的发展，许多更特异性的治疗选择将变得可用。基因疗法有可能在调节眼睛微环境的不同步骤中干扰免疫反应。在本章中，我们将注意力集中在眼免疫疾病的基因治疗中最有前途的候选基因上。此外，我们概述了目前在眼科领域传递目的基因及其潜在优缺点的技术。这些方法中的许多仍处于临床相关免疫介导疾病的治疗研究的早期阶段。