Glaucoma is a leading cause of world blindness, and retinal ganglion cell death is its pathological hallmark. There is accumulating evidence that glaucomatous damage extends from retinal ganglion cells to vision centers in the brain. In an experimental primate model of unilateral glaucoma, degenerative changes are observed in magnocellular, parvocellular, and koniocellular pathways in the lateral geniculate nucleus, and these changes are presented in relation to intraocular pressure and the severity of optic nerve damage. Neuropathological findings are also present in lateral geniculate nucleus layers driven by the unaffected fellow eye. Finally, there is information on changes in the visual cortex in relation to varying degrees of retinal ganglion cell loss. The implications of these findings for refining concepts regarding the pathobiology of progression, and the detection and treatment of glaucoma, are discussed.

中文翻译：

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视网膜神经节细胞丢失对青光眼外侧膝状核和视觉皮层的magno-，parvo-，koniocellular通路的影响。

青光眼是世界失明的主要原因，视网膜神经节细胞死亡是其病理特征。越来越多的证据表明，青光眼的损害从视网膜神经节细胞扩展到大脑的视觉中心。在单侧青光眼的灵长类灵长类动物实验模型中，在外侧膝状核中的巨细胞，细小细胞和新生细胞通路中观察到了退化性变化，这些变化与眼内压和视神经损伤的严重程度有关。神经病理学发现也存在于未受影响的同伴眼睛驱动的外侧膝状核层中。最后，关于视网膜神经节细胞丧失程度不同，有关视觉皮层变化的信息。