Coactivators such as cyclic AMP-response-element binding protein (CREB)-binding protein (CBP) and p300/CBP associated factor (P/CAF) play a crucial role in coordinating and cointegrating eukaryotic transcription. One of the recent paradigms in the eukaryotic transcription field is the finding of molecular basis of coactivator function. The well characterized coactivators such as CBP and P/CAF have been proposed to coactivate/cointegrate gene expression with many transcription activators through two mechanisms. One is complex formation with the components with basal transcriptional machinery. Another is its intrinsic and associated enzymatic activity, which transfers an acetyl-base to the epsilon ( epsilon ) portion of lysine-residues in histones and certain nuclear proteins (factor acetyltransferases; FATs), such as p53, lymphoid enhancer-binding factor (LEF), and transcription factor IIE (TFIIE), which often results in increased transcriptional activity. Recently, the status of hyper nuclear acetylation (HNA) has been thought to influence proliferation, differentiation and apoptosis. Furthermore, recent reports showed that histone acetyltransferase (HAT) activity is increased in human disease, such as cancer and atherosclerosis, and studies have shown associations between nuclear acetylation/deacetylation and cell proliferation/differentiation.

中文翻译：

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高核乙酰化（HNA）在增殖，分化和凋亡中的作用。

诸如环AMP反应元件结合蛋白（CREB）结合蛋白（CBP）和p300 / CBP相关因子（P / CAF）的共激活剂在协调和共整合真核转录中起着至关重要的作用。真核转录领域的最新范例之一是发现了共激活功能的分子基础。已经提出了表征良好的共激活因子，例如CBP和P / CAF，可通过两种机制与许多转录激活因子共激活/共整合基因表达。一种是利用基础转录机制与组分形成复杂的复合物。另一个是它的固有和相关的酶促活性，它将乙酰基转移到组蛋白和某些核蛋白（因子乙酰基转移酶； FATs）中的赖氨酸残基的ε（ε）部分，例如p53，淋巴增强因子结合因子（LEF）和转录因子IIE（TFIIE），通常会导致转录活性增加。最近，人们认为高核乙酰化（HNA）的状态会影响增殖，分化和凋亡。此外，最近的报道显示在诸如癌症和动脉粥样硬化的人类疾病中组蛋白乙酰转移酶（HAT）活性增加，并且研究表明核乙酰化/去乙酰化与细胞增殖/分化之间存在关联。