Even though the blood supply is very safe, the risk of transfusion transmitted disease is not zero. To improve the safety of the blood supply, pathogen reduction (PR) technology has been developed. The principle of most current PR strategies involves modifying DNA or RNA templates and making them inaccessible to DNA or RNA polymerase. Several platforms of pathogen reduction are available including psoralens, alkylating compounds, binary ethyleneimine-like compounds, riboflavin, methylene blue, and solvent-detergent treatment. PR systems have been designed for RBC, plasma, and platelets. PR technology has been found to be effective for a variety of pathogens including lipid-enveloped and non-enveloped viruses, bacteria and parasites. Pre-clinical studies and Phase III clinical trials to evaluate the efficacy and safety of these PR technologies are currently ongoing.

中文翻译：

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血液供应的安全性：减少病原体的作用。

即使血液供应非常安全，输血传播疾病的风险也不为零。为了提高血液供应的安全性，已开发出减少病原体（PR）的技术。当前大多数PR策略的原理都涉及修饰DNA或RNA模板，并使DNA或RNA聚合酶无法使用它们。现有几种减少病原体的平台，包括补骨脂素，烷基化化合物，二元亚乙基亚胺样化合物，核黄素，亚甲基蓝和溶剂去污剂处理。PR系统已设计用于RBC，血浆和血小板。已发现PR技术可有效治疗多种病原体，包括脂质包裹的和非包裹的病毒，细菌和寄生虫。