Type 2 diabetes (T2DM) is a serious disease with severe complications. Around one in 10 people alive today suffer from type 2 diabetes or are destined to develop it before they die. Inheritance plays an important role in the cause of type 2 diabetes. A considerable amount of research is devoted to defining the genes involved in the aetiology of this widespread disease. This information is crucial if we are to improve our methods of preventing and treating diabetes. Over the last 25 years there have been considerable advances in our understanding of the genetics of diabetes. Important discoveries have been made in dissecting the genes involved in rare monogenic forms of type 2 diabetes which has become a paradigm for genetic studies of type 2 diabetes. This review focuses on the main approaches currently adopted and our current understanding of the genes involved in susceptibility to type 2 diabetes.

中文翻译：

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寻找2型糖尿病基因。

2型糖尿病（T2DM）是一种具有严重并发症的严重疾病。今天，大约有十分之一的人还患有2型糖尿病，或者注定要在死之前发展这种疾病。遗传在2型糖尿病的起因中起着重要作用。大量的研究致力于定义与这种广泛疾病的病因有关的基因。如果我们要改善预防和治疗糖尿病的方法，则此信息至关重要。在过去的25年中，我们对糖尿病遗传学的理解有了长足的进步。在解剖涉及2型糖尿病的罕见单基因形式的基因方面已获得重要发现，该基因已成为2型糖尿病基因研究的范例。