The corneal epithelium serves as a barrier and contributes to the maintenance of corneal transparency and rigidity. In most instances, corneal epithelial defects caused by simple injury are resurfaced promptly. However, in individuals with certain clinical conditions, such as herpes simplex virus infection, neurotrophic keratopathy or diabetic keratopathy, corneal epithelial defects persist and do not respond to conventional treatment regimens because of delayed epithelial wound healing. After the corneal epithelium is removed by injury, the remaining epithelial cells migrate over the denuded surface of the cornea in a manner that is dependent both on the interaction of the cells with the underlying substrate and on cell-cell adhesion. In this review, we describe the specific roles of cell-matrix and cell-cell interactions during the course of corneal epithelial wound healing. The clinical implications of the basic research findings are also discussed.

中文翻译：

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角膜上皮伤口愈合过程中的细胞基质和细胞间相互作用。

角膜上皮用作屏障并有助于维持角膜透明性和刚性。在大多数情况下，由简单损伤引起的角膜上皮缺损会迅速恢复。然而，在具有某些临床状况的个体中，例如单纯疱疹病毒感染，神经营养性角膜病或糖尿病性角膜病，由于延迟的上皮伤口愈合，角膜上皮缺陷持续存在并且对常规治疗方案无反应。在通过损伤去除角膜上皮之后，剩余的上皮细胞以既取决于细胞与下面的底物的相互作用又取决于细胞-细胞粘附的方式在角膜的裸露表面上迁移。在这篇评论中 我们描述了角膜上皮伤口愈合过程中细胞-基质和细胞间相互作用的特定作用。还讨论了基础研究结果的临床意义。