Over the last decade, pediatric thrombophilia programs have emerged around the world as a new discipline in pediatric hematology. These programs specialize in the diagnosis, prevention and treatment of children with thromboembolic events (TEs) in both the venous and arterial systems. The need for separate pediatric programs has been discussed previously. (J Pediatr Hematol Oncol 1997; 19: 7-22.) The following article will update previous reviews (Hematol Oncol Clin North Am 1998; 12: 1283-1312; Thromb Haemost 1997; 78: 715-725) and will concentrate on three aspects: (1) The risk factors for acquiring TEs; (2) The confirmatory diagnostic tests used in children with TEs; and (3) The different antithrombotic agents used for prevention and treatment. The current knowledge in respect to the above points is only the "tip of the iceberg". Well-designed prospective trials are required to establish the contribution of congenital prothrombotic disorders, appropriate diagnostic strategies, and optimal therapy for children with TEs.

中文翻译：

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儿童血栓栓塞性疾病。

在过去的十年中，儿科血栓形成计划作为儿科血液学的一门新学科在世界范围内兴起。这些程序专门针对静脉和动脉系统中发生血栓栓塞事件（TEs）的儿童进行诊断，预防和治疗。先前已经讨论了对单独的儿科程序的需求。（J Pediatr Hematol Oncol 1997; 19：7-22。）以下文章将更新以前的评论（Hematol Oncol Clin North Am 1998; 12：1283-1312; Thromb Haemost 1997; 78：715-725），并将重点介绍三篇文章。方面：（1）获得TE的风险因素；（2）对TEs患儿进行的确诊诊断测试；（3）用于预防和治疗的不同抗栓剂。关于以上几点的当前知识仅仅是“冰山一角”。