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Nanocarriers in photodynamic therapy-in vitro and in vivo studies.
WIREs Nanomedicine and Nanobiotechnology ( IF 6.9 ) Pub Date : 2019-11-06 , DOI: 10.1002/wnan.1599
Krzysztof Sztandera 1 , Michał Gorzkiewicz 1 , Barbara Klajnert-Maculewicz 1, 2
Affiliation  

Photodynamic therapy (PDT) is a minimally invasive technique which has proven to be successful in the treatment of several types of tumors. This relatively simple method exploits three inseparable elements: phototoxic compound (photosensitizer [PS]), light source, and oxygen. Upon irradiation by light with specified wavelength, PS generates reactive oxygen species, which starts the cascade of reactions leading to cell death. The positive therapeutic outcome of PDT may be limited due to several aspects, including low water solubility of PSs, hampering their effective administration and blood circulation, as well as low tumor specificity, inefficient cellular uptake and activation energies requiring prolonged illumination times. One of the promising approaches to overcome these obstacles involves the use of carrier systems modulating pharmacokinetics and pharmacodynamics of the PSs. In the present review, we summarized current in vitro and in vivo studies regarding the use of nanoparticles as potential delivery devices for PSs to enhance their cellular uptake and cytotoxic properties, and thus-the therapeutic outcome of PDT. This article is categorized under: Therapeutic Approaches and Drug Discovery > Emerging Technologies Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease.

中文翻译:

纳米载体在光动力疗法中的体外和体内研究。

光动力疗法(PDT)是一种微创技术,已被证明可成功治疗多种类型的肿瘤。这种相对简单的方法利用了三个不可分割的元素:光毒化合物(光敏剂[PS]),光源和氧气。在用指定波长的光照射后,PS会生成活性氧,从而开始级联反应,导致细胞死亡。PDT的积极治疗结果可能由于以下几个方面而受到限制,包括PS的水溶性低,妨碍其有效给药和血液循环以及肿瘤特异性低,细胞吸收效率低和活化能低,需要延长照明时间。克服这些障碍的有前途的方法之一涉及使用载体系统调节PS的药代动力学和药效学。在本综述中,我们总结了当前的体外和体内研究,这些研究涉及使用纳米颗粒作为PS的潜在递送装置,以增强其细胞摄取和细胞毒性,从而提高PDT的治疗效果。本文归类于:治疗方法和药物发现>生物学的新兴技术纳米技术方法>生物治疗方法和药物发现中的纳米系统>肿瘤疾病的纳米药物。我们总结了当前有关使用纳米粒子作为PS潜在的递送装置以增强其细胞摄取和细胞毒性特性以及PDT的治疗效果的体外和体内研究。本文归类于:治疗方法和药物发现>生物学的新兴技术纳米技术方法>生物治疗方法和药物发现中的纳米系统>肿瘤疾病的纳米药物。我们总结了当前有关使用纳米粒子作为PS潜在的递送装置以增强其细胞摄取和细胞毒性特性以及PDT的治疗效果的体外和体内研究。本文归类于:治疗方法和药物发现>生物学的新兴技术纳米技术方法>生物治疗方法和药物发现中的纳米系统>肿瘤疾病的纳米药物。
更新日期:2019-11-01
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