Precise management of the spatiotemporal position of subcellular components is critical to a number of essential processes in the bacterial cell. The bacterial nucleoid is a highly structured yet dynamic object that undergoes significant reorganization during the relatively short cell cycle, e.g. during gene expression, chromosome replication, and segregation. Although the nucleoid takes up a large fraction of the volume of the cell, the mobility of macromolecules within these dense regions is relatively high and recent results suggest that the nucleoid plays an integral role of dynamic localization in a host of seemingly disparate cellular processes. Here, we review a number of recent reports of nucleoid-mediated positioning and transport in the model bacteria Escherichia coli. These results viewed as a whole suggest that the dynamic, cellular-scale structure of the nucleoid may be a key driver of positioning and transport within the cell. This model of a global, default positioning and transport system may help resolve many unanswered questions about the mechanisms of partitioning and segregation in bacteria.

中文翻译：

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核素介导的细菌定位和运输。

亚细胞成分的时空位置的精确管理对于细菌细胞中的许多基本过程至关重要。细菌核苷是一种高度结构化但充满活力的物体，在相对较短的细胞周期内（例如在基因表达，染色体复制和分离过程中）会发生重大重组。尽管核苷占据了细胞体积的很大一部分，但是大分子在这些致密区域内的迁移率却相对较高，最近的结果表明，核苷在许多看似完全不同的细胞过程中起着动态定位的整体作用。在这里，我们回顾了模型细菌大肠杆菌中核苷介导的定位和运输的最新报道。从整体来看，这些结果表明，动态，核苷的细胞规模结构可能是细胞内定位和运输的关键驱动力。这种全球性的默认定位和运输系统模型可以帮助解决有关细菌分配和分离机制的许多悬而未决的问题。