The serine glycine and one-carbon pathway (SGOCP) is a crucially important metabolic network for tumorigenesis, of unanticipated complexity, and with implications in the clinic. Solving how this network is regulated is key to understanding the underlying mechanisms of tumor heterogeneity and therapy resistance. Here, we review its role in cancer by focusing on key enzymes with tumor-promoting functions and important products of the SGOCP that are of physiological relevance for tumorigenesis. We discuss the regulatory mechanisms that coordinate the metabolic flux through the SGOCP and their deregulation, as well as how the actions of this metabolic network affect other cells in the tumor microenvironment, including endothelial and immune cells.

中文翻译：

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癌症中丝氨酸甘氨酸一碳途径的复杂性

丝氨酸甘氨酸和一碳途径（SGOCP）是肿瘤发生中至关重要的代谢网络，其复杂性难以预料，并且对临床具有重要意义。解决该网络的调节方式是理解肿瘤异质性和治疗耐药性的潜在机制的关键。在这里，我们通过重点关注具有促肿瘤功能的关键酶以及与肿瘤发生具有生理相关性的 SGOCP 的重要产物来回顾其在癌症中的作用。我们讨论了通过 SGOCP 协调代谢流的调节机制及其解除管制，以及该代谢网络的作用如何影响肿瘤微环境中的其他细胞，包括内皮细胞和免疫细胞。