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Novel reassortant of H1N1 swine influenza virus detected in pig population in Russia.
Emerging Microbes & Infections ( IF 13.2 ) Pub Date : 2019-01-01 , DOI: 10.1080/22221751.2019.1673136
Ivan Sobolev 1 , Olga Kurskaya 1 , Sergey Leonov 2 , Marsel Kabilov 3 , Tatyana Alikina 3 , Alexander Alekseev 1 , Yuriy Yushkov 2 , Takehiko Saito 4 , Yuko Uchida 4 , Junki Mine 4 , Alexander Shestopalov 1 , Kirill Sharshov 1
Affiliation  

Pigs play an important role in interspecies transmission of the influenza virus, particularly as "mixing vessels" for reassortment. Two influenza A/H1N1 virus strains, A/swine/Siberia/1sw/2016 and A/swine/Siberia/4sw/2017, were isolated during a surveillance of pigs from private farms in Russia from 2016 to 2017. There was a 10% identity difference between the HA and NA nucleotide sequences of isolated strains and the most phylogenetically related sequences (human influenza viruses of 1980s). Simultaneously, genome segments encoding internal proteins were found to be phylogenetically related to the A/H1N1pdm09 influenza virus. In addition, two amino acids (129-130) were deleted in the HA of A/swine/Siberia/4sw/2017 compared to that of A/swine/Siberia/1sw/2016 HA.

中文翻译:

在俄罗斯的猪群中发现了新型H1N1猪流感病毒重配株。

猪在流感病毒的种间传播中起着重要作用,特别是作为“混合容器”进行重组。在2016年至2017年对俄罗斯私人农场的猪进行监视期间,分离出了两种A / H1N1流感病毒株A / swine / Siberia / 1sw / 2016和A / swine / Siberia / 4sw / 2017。其中有10%分离菌株的HA和NA核苷酸序列与最亲缘关系最密切的序列(1980年代人类流感病毒)之间的同一性差异。同时,发现编码内部蛋白质的基因组片段与A / H1N1pdm09流感病毒在系统发育上相关。另外,与A / swine / Siberia / 1sw / 2016 HA的HA相比,A / swine / Siberia / 4sw / 2017的HA中缺失了两个氨基酸(129-130)。
更新日期:2019-11-01
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