This paper presents the current knowledge concerning the role of polymorphisms of IL1A and IL1B genes in periodontitis. Attention has been paid to the role of IL-1 in the pathogenesis of the disease, and to the significance of a genetic test, investigating the presence of composite two polymorphisms of IL-1 gene, as a risk factor for severe periodontitis. The significance of this test for prevention of periodontitis and its therapy has been discussed. IL-1 polymorphisms have been presented and described according to the reference single nucleotide polymorphism (SNP) identification number (rsID), established to eradicate the redundancy of reported polymorphisms in the SNP database processed by the National Center for Biotechnology Information. The prevalence of these genotypes in different populations and ethnic groups and its effect on periodontal health have been discussed. The presented data show inconsistent results. It seems that at least two polymorphisms, rs1800587 and rs1143634, are associated with periodontal inflammation. Therefore, they can be regarded as candidate genes involved in further periodontitis risk assessment. It seems that geographical and ethnical factors can play a great role, as the prevalence of specific polymorphisms varies greatly depending on the population studied.

中文翻译：

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牙周炎的白细胞介素-1基因型。

本文介绍了有关IL1A和IL1B基因多态性在牙周炎中作用的最新知识。已经注意到IL-1在该疾病的发病机理中的作用以及遗传测试的重要性，该研究调查了IL-1基因复合的两个多态性的存在，作为严重牙周炎的危险因素。讨论了该测试对预防牙周炎及其治疗的意义。已经根据参考单核苷酸多态性（SNP）识别号（rsID）提出并描述了IL-1多态性，该参考号是为了消除国家生物技术信息中心处理的SNP数据库中报告的多态性的冗余而建立的。讨论了这些基因型在不同人群和种族中的流行及其对牙周健康的影响。显示的数据显示不一致的结果。看来至少有两个多态性rs1800587和rs1143634与牙周炎有关。因此，它们可以被认为是参与进一步的牙周炎风险评估的候选基因。似乎地理和种族因素可以发挥重要作用，因为特定多态性的流行程度取决于所研究的人群而有很大差异。