Entamoeba histolytica is the third-leading cause of parasitic mortality globally. E. histolytica infection generally does not cause symptoms, but the parasite has potent pathogenic potential. The origins, benefits, and triggers of amoebic virulence are complex. Amoebic pathogenesis entails depletion of the host mucosal barrier, adherence to the colonic lumen, cytotoxicity, and invasion of the colonic epithelium. Parasite damage results in colitis and, in some cases, disseminated disease. Both host and parasite genotypes influence the development of disease, as do the regulatory responses they govern at the host-pathogen interface. Host environmental factors determine parasite transmission and shape the colonic microenvironment E. histolytica infects. Here we highlight research that illuminates novel links between host, parasite, and environmental factors in the regulation of E. histolytica virulence.

中文翻译：

---

溶组织内阿米巴毒力的调节。

溶组织内阿米巴是全球寄生虫死亡的第三大原因。E. histolytica 感染一般不会引起症状，但该寄生虫具有强大的致病潜力。阿米巴毒力的起源、益处和诱因是复杂的。阿米巴病的发病机制包括宿主粘膜屏障的耗竭、对结肠腔的粘附、细胞毒性和结肠上皮的侵袭。寄生虫损害会导致结肠炎，在某些情况下会导致传播性疾病。宿主和寄生虫基因型都会影响疾病的发展，它们在宿主-病原体界面上控制的调节反应也是如此。宿主环境因素决定了寄生虫的传播并塑造了溶组织大肠杆菌感染的结肠微环境。在这里，我们重点介绍阐明宿主、寄生虫、