Platinum (Pt) salts are potent occupational allergens in precious metal refineries and catalyst productions. The threshold limit value of 2000 ng soluble Pt/m3 enforced in many countries has been questioned because there is still a high incidence of Pt salt allergy. The objective of the present case series is to define the predictive value of biological monitoring by relating Pt in the serum of catalyst production workers and control subjects to sensitization to Pt salts as assessed by skin prick testing. A total of 38 Pt measurements were taken from sera of six workers investigated several times during a 5-year cohort study. Three subjects showed a conversion of skin prick test (SPT) with Pt salts from negative to positive during the cohort study (all considered highly exposed to Pt), and three did not show SPT conversion. Previous therapy with Pt-containing anti-cancer drugs and metallic dental alloys were considered as confounders. Only one of the three workers sensitized to Pt salt had clearly elevated serum Pt concentrations, but this elevation was not observed in each examination. Elevated Pt concentrations were also found in two subjects with low or no exposure to Pt. Both had metallic dental alloys. One control subject without metallic dental alloys showed low Pt concentrations in the serum in four examinations, but a single unexplained high concentration in his initial examination. In this small case series, serum Pt concentrations were neither sensitive nor specific for the prediction of Pt salt sensitization. Low specificity may be explained by Pt-containing metallic dental alloys, but additional unknown confounders may be of importance.

中文翻译：

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催化剂生产工人血清中的铂浓度不能预测铂盐过敏。

铂（Pt）盐是贵金属精炼厂和催化剂生产中的强效职业过敏原。许多国家对2000 Png / m3可溶性Pt / m3的极限限值提出了质疑，因为Pt盐过敏的发生率仍然很高。本案例系列的目的是通过将催化剂生产工人和控制对象血清中的Pt与通过皮肤点刺试验评估的对Pt盐的敏感性相关联，从而定义生物学监测的预测价值。在为期5年的队列研究中，对6名工人的血清进行了38次Pt测量，并对其进行了多次调查。在队列研究中，三名受试者表现出皮肤点刺试验（SPT）的Pt盐从阴性转变为阳性（均被认为高度暴露于Pt），三名受试者未显示SPT转化。以前使用含Pt的抗癌药和金属牙科合金进行治疗被认为是混杂因素。对Pt盐敏感的三名工人中只有一名明显升高了血清Pt浓度，但在每次检查中均未观察到这种升高。在有很少或没有暴露于Pt的两个受试者中也发现Pt浓度升高。两者都具有金属牙科合金。一位没有金属牙科合金的对照受试者在四次检查中显示出较低的血清Pt浓度，但在其初始检查中出现了一个无法解释的高浓度。在这个小病例系列中，血清Pt浓度对Pt盐致敏性的预测既不敏感也不特异性。特异性较低的原因可能是含Pt的金属牙科合金，但其他未知的混杂因素可能很重要。