Acetyl-CoA carboxylase (ACC) catalyses the first committed step of fatty acid synthesis, the carboxylation of acetyl-CoA to malonyl-CoA. Two physically distinct types of enzymes are found in nature. Bacterial and most plant chloroplasts contain a multi-subunit ACC (MS-ACC) enzyme that is readily dissociated into its component proteins. Mammals, fungi, and plant cytosols contain the second type of ACC, a single large multifunctional polypeptide. This review will focus on the structures, regulation, and enzymatic mechanisms of the bacterial and plant MS-ACCs.

中文翻译：

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多亚基的乙酰辅酶A羧化酶。

乙酰辅酶A羧化酶（ACC）催化脂肪酸合成的第一个重要步骤，即乙酰辅酶A羧化为丙二酰辅酶A。在自然界中发现了两种物理上不同的酶。细菌和大多数植物的叶绿体都含有一个多亚基ACC（MS-ACC）酶，该酶很容易分解成其组成蛋白。哺乳动物，真菌和植物细胞质含有第二种类型的ACC，即单一的大型多功能多肽。这项审查将侧重于细菌和植物MS-ACC的结构，调控和酶促机制。