The lysophospholipids, lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P), are now recognized as important extracellular signaling molecules. These lipid mediators are pleiotropic; among the most common cellular responses are mitogenesis, cell survival (anti-apoptosis), inhibition of adenylyl cyclase and calcium mobilization. Physiologic events associated with these mediators include platelet aggregation, vasopressor activity, wound healing, immune modulation, and angiogenesis. Many of the actions of LPA and S1P are mediated through a set of eight G protein-coupled receptors. Five of these are S1P-prefering while the remaining three are LPA receptors. These receptors are expressed widely and in aggregate signal through a variety of heterotrimeric G proteins. The lysophospholipid receptor family is referred to commonly as the "Edg" group (e.g., Edg-1, Edg-2, etc.). Herein, the molecular pharmacology of the lysophospholipid receptors is reviewed briefly, and a rational nomenclature for LPA and S1P receptors that is consistent with the International Union of Pharmacology guidelines is proposed.

中文翻译：

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国际药理学联合会。XXXIV。溶血磷脂受体命名法。

溶血磷脂，溶血磷脂酸（LPA）和鞘氨醇1-磷酸（S1P）现在被认为是重要的细胞外信号分子。这些脂质介体是多效的。最常见的细胞反应包括促有丝分裂，细胞存活（抗凋亡），腺苷酸环化酶抑制和钙动员。与这些介质有关的生理事件包括血小板聚集，升压活性，伤口愈合，免疫调节和血管生成。LPA和S1P的许多作用是通过一组八个G蛋白偶联受体介导的。其中五个是S1P首选，其余三个是LPA受体。这些受体通过多种异源三聚体G蛋白广泛表达并以总信号表达。溶血磷脂受体家族通常被称为“