A series of new taxoids, named taxuspines A-H and J-Z (1-25) and taxezopidines A-H and J-L (26-36), have been isolated together with 37 known taxoids (37-73) including paclitaxel (53) from the Japanese yew, Taxus cuspidata Sieb. et Zucc. (Taxaceae). These new taxoids possess various skeletons containing 5/7/6, 6/10/6, 6/5/5/6, 6/8/6, or 6/12-membered ring systems. Among the new taxoids, some non-taxol-type compounds remarkably reduced CaCl(2)-induced depolymerization of microtubules, or increased cellular accumulation of vincristine in multidrug-resistant tumor cells as potent as verapamil. On the other hand, chemical derivatization of taxinine (37), one of major taxoids obtained from this yew, led to the discovery of unusual reactions of taxinine derivatives. Here we describe our recent results on the isolation, structure elucidation, and bioactivity of these new and known taxoids and the formation of unexpected products of the unusual reactions of taxinine.

中文翻译：

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紫杉红豆杉的生物活性类紫杉。

从日本紫杉中分离出了一系列新的紫杉醇类，分别命名为紫杉醇AH和JZ（1-25）和紫杉烷类化合物AH和JL（26-36），以及37种已知紫杉醇（37-73），包括紫杉醇（53），东北红豆杉。et Zucc。（菊科）。这些新的类紫杉醇具有各种骨架，其中包含5/7 / 6、6 / 10 / 6、6 / 5/5 / 6、6 / 8/6或6/12元环系统。在新的类紫杉醇中，一些非紫杉醇类化合物显着降低CaCl（2）诱导的微管解聚，或增加长春新碱在多药耐药肿瘤细胞中的细胞蓄积，其效力与维拉帕米一样强。另一方面，紫杉碱的化学衍生化（37）是从紫杉中获得的主要类紫杉醇之一，导致发现了紫杉碱衍生物的异常反应。在这里，我们描述了有关隔离，结构阐明，