Most biological membranes possess an asymmetric transbilayer distribution of phospholipids. Endogenous enzymes expend energy to maintain the arrangement by promoting the rate of phospholipid translocation, or flip-flop. Researchers have discovered ways to modify this distribution through the use of chemicals. This review presents a critical analysis of the phospholipid asymmetry data in the literature followed by a brief overview of the maintenance and physiological consequences of phospholipid asymmetry, and finishes with a list of chemical ways to alter phospholipid distribution by enhancement of flip-flop.

中文翻译：

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跨双层膜的磷脂分布的化学控制。

大多数生物膜具有磷脂的不对称跨双分子层分布。内源性酶通过提高磷脂转运或翻转的速率来消耗能量以维持排列。研究人员发现了通过使用化学物质来改变这种分布的方法。这篇综述对文献中的磷脂不对称数据进行了严格的分析，然后简要概述了磷脂不对称的维持和生理后果，并列举了一系列通过增强触发器来改变磷脂分布的化学方法。