Erectile function was assessed 6 weeks following uni- and bilateral injections of 6-hydroxydopamine in the substantia nigra nucleus of the brain. Behavioral apomorphine-induced penile erections were reduced (5/8) and increased (3/8) in uni- and bilateral lesioned animals. Intracavernous pressures, following electrical stimulation of the cavernous nerve, decreased in lesioned animals. Lesions of the substantia nigra were confirmed by histology. Concentration of dopamine and its metabolites were decreased in the striatum of substantia nigra lesioned rats. Lesions of the substantia nigra are therefore associated with erectile dysfunction in rats and may serve as a model to study erectile dysfunction in Parkinson's disease.

中文翻译：

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在大鼠黑质实质性损伤后会出现勃起功能障碍。

在黑质黑质核中单次和双次注射6-羟基多巴胺后6周评估勃起功能。行为阿朴吗啡诱导的阴茎勃起在单侧和双侧患病动物中减少（5/8）和增加（3/8）。在患病动物中，电刺激海绵状神经后，海绵体内压力降低。组织学证实了黑质的病变。黑质病变大鼠纹状体中多巴胺及其代谢物的浓度降低。因此，黑质的病变与大鼠的勃起功能障碍有关，并可作为研究帕金森氏病勃起功能障碍的模型。